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Effect of a Single Hemodialysis Session on Hemostatic Function in Patients With Chronic Kidney Disease

Iman Sami AbdulAmeer1, Noor Thamer Hamood1, Roaa Waleed Dawood Hussein1, Anwar Khalil Ismael1, Ghaith I.S. Alwani1
1Department of Analytical Pathology, College of Applied Science, University of Fallujah, Anbar, Iraq
DOI: https://doi.org/10.70517/revcc2624155
Published: 13/10/2026
: Iman Sami AbdulAmeer, Noor Thamer Hamood, Roaa Waleed Dawood Hussein, Anwar Khalil Ismael, Ghaith I.S. Alwani. Effect of a Single Hemodialysis Session on Hemostatic Function in Patients With Chronic Kidney Disease. Revista Cultura Científica, 2026 Issue 24. pg. 1851-1865.

Abstract

Chronic kidney disease (CKD) is associated with complex disturbances in hemostasis that may increase susceptibility to both bleeding and thrombotic complications. Hemodialysis, an essential treatment for advanced CKD, may further influence hematological and coagulation measurements through extracorporeal blood circulation, fluid removal, and anticoagulation. This observational study assessed changes in selected hematological and coagulation parameters immediately before and after a single hemodialysis session. Thirty-two patients receiving maintenance hemodialysis at Al-Fallujah Teaching Hospital were enrolled, and paired blood specimens were analyzed using complete blood count measurements and routine coagulation assays, including prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, and D-dimer. Most hematological comparisons were based on 31 paired measurements, whereas coagulation parameters were available for 32 participants. WBC and neutrophil counts, RBC count, hemoglobin, and hematocrit showed statistically significant post-dialysis increases in the reported analyses. Platelet count and routine platelet indices showed no significant differences. PT and APTT decreased slightly, while fibrinogen and D-dimer increased modestly; none of these coagulation differences reached statistical significance. These results suggest that one hemodialysis session is associated with selective short-term changes in circulating blood-cell measurements, whereas conventional coagulation indices remained relatively stable in this small cohort. Larger studies that document anticoagulation, fluid removal, and additional measures of platelet and coagulation function are warranted to clarify the mechanisms and clinical relevance of these findings.

Keywords: chronic kidney disease; hemodialysis; hemostasis; coagulation; platelets; D-dimer

Abstract

Chronic kidney disease (CKD) is associated with complex disturbances in hemostasis that may increase susceptibility to both bleeding and thrombotic complications. Hemodialysis, an essential treatment for advanced CKD, may further influence hematological and coagulation measurements through extracorporeal blood circulation, fluid removal, and anticoagulation. This observational study assessed changes in selected hematological and coagulation parameters immediately before and after a single hemodialysis session. Thirty-two patients receiving maintenance hemodialysis at Al-Fallujah Teaching Hospital were enrolled, and paired blood specimens were analyzed using complete blood count measurements and routine coagulation assays, including prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, and D-dimer. Most hematological comparisons were based on 31 paired measurements, whereas coagulation parameters were available for 32 participants. WBC and neutrophil counts, RBC count, hemoglobin, and hematocrit showed statistically significant post-dialysis increases in the reported analyses. Platelet count and routine platelet indices showed no significant differences. PT and APTT decreased slightly, while fibrinogen and D-dimer increased modestly; none of these coagulation differences reached statistical significance. These results suggest that one hemodialysis session is associated with selective short-term changes in circulating blood-cell measurements, whereas conventional coagulation indices remained relatively stable in this small cohort. Larger studies that document anticoagulation, fluid removal, and additional measures of platelet and coagulation function are warranted to clarify the mechanisms and clinical relevance of these findings.

Keywords: chronic kidney disease; hemodialysis; hemostasis; coagulation; platelets; D-dimer

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Iman Sami AbdulAmeer
Department of Analytical Pathology, College of Applied Science, University of Fallujah, Anbar, Iraq
Noor Thamer Hamood
Department of Analytical Pathology, College of Applied Science, University of Fallujah, Anbar, Iraq
Roaa Waleed Dawood Hussein
Department of Analytical Pathology, College of Applied Science, University of Fallujah, Anbar, Iraq
Anwar Khalil Ismael
Department of Analytical Pathology, College of Applied Science, University of Fallujah, Anbar, Iraq
Ghaith I.S. Alwani
Department of Analytical Pathology, College of Applied Science, University of Fallujah, Anbar, Iraq
ghaith.ismail@uofallujah.edu.iq

How to cite:

Iman Sami AbdulAmeer, Noor Thamer Hamood, Roaa Waleed Dawood Hussein, Anwar Khalil Ismael, Ghaith I.S. Alwani. Effect of a Single Hemodialysis Session on Hemostatic Function in Patients With Chronic Kidney Disease. Revista Cultura Científica, 2026 Issue 24. pg. 1851-1865.

Publication History

  • Received: 09/06/2026
  • Accepted: 01/10/2026
  • Published: 13/10/2026
Copyright © 2026, Iman Sami AbdulAmeer, Noor Thamer Hamood, Roaa Waleed Dawood Hussein, Anwar Khalil Ismael, Ghaith I.S. Alwani. Published by Revista Cultura Científica. This article is published as open access under the Creative Commons Attribution 4.0 International (CC BY 4.0) license (http://creativecommons.org/licenses/by/4.0/).

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