Background: Leptin and adiponectin are two major adipokines involved in the regulation of energy balance, glucose metabolism, and insulin sensitivity. These adipokines are also expected to have an important role in the development of type 2 diabetes mellitus (T2DM).
Objective: To measure the levels of leptin, adiponectin, progesterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) in Iraqi patients with type 2 diabetes who are obese or non-obese.
Methods: The 120 participants in this study were divided into three groups: Group 2 (G2) included 40 obese patients with type 2 diabetes, Group 3 (G3) included 40 non-obese patients with type 2 diabetes, and Group 1 (G1) was an age- and sex-matched healthy control group.
Results: Leptin concentrations were significantly elevated in the T2DM and T2DM-obese groups compared with the control group. Adiponectin levels were markedly reduced in the T2DM groups. LH was lowered in the T2DM non-obese group only. FSH and progesterone levels were downregulated only in the T2DM obese group.
Conclusion: According to patient weight status, leptin and adiponectin may have important diagnostic value during the course of type 2 diabetes mellitus.
Background: Leptin and adiponectin are two major adipokines involved in the regulation of energy balance, glucose metabolism, and insulin sensitivity. These adipokines are also expected to have an important role in the development of type 2 diabetes mellitus (T2DM).
Objective: To measure the levels of leptin, adiponectin, progesterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) in Iraqi patients with type 2 diabetes who are obese or non-obese.
Methods: The 120 participants in this study were divided into three groups: Group 2 (G2) included 40 obese patients with type 2 diabetes, Group 3 (G3) included 40 non-obese patients with type 2 diabetes, and Group 1 (G1) was an age- and sex-matched healthy control group.
Results: Leptin concentrations were significantly elevated in the T2DM and T2DM-obese groups compared with the control group. Adiponectin levels were markedly reduced in the T2DM groups. LH was lowered in the T2DM non-obese group only. FSH and progesterone levels were downregulated only in the T2DM obese group.
Conclusion: According to patient weight status, leptin and adiponectin may have important diagnostic value during the course of type 2 diabetes mellitus.
